Key Findings:  Resulting data found that in cases of autistic children and rat models of ASD exhibited a reduction in endocannabinoids, increased degradation of enzymes and upregulation of endocannabinoid receptor sites. In animals, the researchers reported that the use of a selective inhibitor of monoacylglycerol lipase (MAGL), the enzyme that metabolizes 2-AG, produced a subsequent reduction of repetitive behaviors, hyperactivity, sociability, social preference as well as an improvement in cognitive function. The authors posit that increasing 2-AG levels may are present a novel treatment option for this patient population.
Type of Study:  Animal Study
Study Result:  Positive
Study Location(s):  China
Year of Pub:  2021
Cannabinoids Studied:  2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Other Related Compounds
Phytocannabinoid Source:  Not Applicable