Expression of GPR55 and either cannabinoid CB 1 or CB 2 heteroreceptor complexes in the caudate, putamen, and accumbens nuclei of control, parkinsonian, and dyskinetic non-human primates

Key Findings:  Complexes formed of a variety of sub-units (heteromers) such as GPR55 and CB1/CB2 receptor sites in the striatum of parkinsonian macaques (with and without levodopa-induced dyskinesia) show an increased expression. As such, the author posit the potential for novel non-dopaminergic targets for PD therapy.

Type of Study:  Animal Study

Study Result:  Positive

Cannabinoids Studied:  Not Applicable

Phytocannabinoid Source:  Not Applicable

Form of Administration:  Not Applicable

Receptors Studied:  CB1, CB2, GPCR 55

Study Location(s):  Spain

Year of Pub:  2020

Link to study