Endocannabinoid Signalling in Parkinson's Disease: A Perspective on Associated Therapeutic Interventions

Key Findings:  In patients with PD endocannabinoids regulate various signaling systems in a bi-directional fashion. These include: the basal ganglia neuronal circuit pathways, synaptic plasticity, and motor functions via communication with dopaminergic, glutamatergic, and GABAergic systems. Therapeutic effects include: neuroprotection, suppression of excitotoxicity, oxidative stress, glial activation, and more.

Type of Study:  Meta-analysis

Study Result:  Positive

Cannabinoids Studied:  Cannabinoid (unspecified), Endocannabinoid (unspecified)

Phytocannabinoid Source:  Not Applicable

Form of Administration:  Not Applicable

Receptors Studied:  CB1, CB2

Study Location(s):  China, India, Romania

Year of Pub:  2020

Link to study