PRIMARY STUDY

Regulation of inflammation and proliferation of human bladder carcinoma cells by type-1 and type-2 cannabinoid receptors

Key Findings:  These data suggest that the body’s own endocannabinoid 2-AG negatively modulates the inflammatory milieu of cancer cells in vitro (via CB1 and CB2 activation) thus potentially increasing proliferation, while AM281 (a CB1 inverse agonist) decreased cancer proliferation.