RELATED STUDY
Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations
Key Findings: This review discusses the activity of the sebaceous gland and the many complex systems that help regulate the inflammatory and immune processes of the cutaneous system and related skin and hair diseases. Among them include the endocannabinoid system, along with sex hormones, peroxisome proliferator-activated receptor ligands, neuro peptides, and a selective apoptotic process.
Type of Study: Meta-analysis
Study Result: Positive
Research Location(s): Belgium, China, Germany, Hungary, Italy, Japan, United States
Year of Pub: 2022
Cannabinoids Studied: Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Endocannabinoid (unspecified), Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV), Palmitoylethanolamide (PEA)
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB1, CB2, GPCR 3, GPCR 6, GPCR 18, GPCR 55, TRPA1, TRPV1, TRPV2, TRPV4, PPAR - Alpha, PPAR - Beta Delta, PPAR - Gamma, GPCR, TRPs, PPARs
Ligands Studied: Anti-inflammatory cytokines, Insulin, Leptin, Serotonin, Pro-inflammatory cytokines
Citation: Zouboulis CC, et al. Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations. Front Immunol. 2022; 13:1029818. doi: 10.3389/fimmu.2022.1029818
Authors: Zouboulis CC, Coenye T, He L, Kabashima K, Kobayashi T, Niemann C, Nomura T, Oláh A, Picardo M, Quist SR, Sasano H, Schneider MR, Törőcsik D, Wong SY
