Key Findings:  This review covers the available research on the use of phyto- and synthetic cannabinoids and the role of the endocannabinoid system in a multitude of oral and periodontal diseases. Overall cannabis and cannabidiol specifically appear to have promising anti-inflammatory, anti-infective, and analgesic effects but the rigor of the evidence is currently lacking. Future research may provide therapeutic options in the management of dental diseases.
Type of Study:  Meta-analysis
Study Result:  Positive
Study Location(s):  Canada, Jamaica, United States
Year of Pub:  2021
Cannabinoids Studied:  Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids, JWH-x Synthetic Cannabinoids, HU-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids, Anandamide (AEA), Cannabinoid (unspecified), Endocannabinoid (unspecified), Pharma THC, Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV), Palmitoylethanolamide (PEA)
Phytocannabinoid Source:  Not Applicable
Receptors Studied:  CB1, CB2, TRPV1, GPCR