Radiation Induced Adverse Effects – Cannabis Research

Radiation-induced adverse effects Research Dashboard

4

Primary Studies

2

Related Studies

6

Total Studies

Clinical Studies

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Clinical Meta-analyses

1

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

2

Animal studies

0

Laboratory studies

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CannaKeys has 6 studies associated with Radiation-induced adverse effects.

Here is a small sampling of Radiation-induced adverse effects studies by title:


Components of the Radiation-induced adverse effects Research Dashboard

  • Dosing information available for Radiation-induced adverse effects
  • Chemotype guidance for treating Radiation-induced adverse effects with cannabis
  • Synopsis of cannabis research for Radiation-induced adverse effects
  • Individual study details for Radiation-induced adverse effects

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Overview - Radiation-induced adverse effects

Description of Radiation-induced adverse effects

Orthodox medicine's approach to cancer usually involves three modalities: chemotherapy, surgery, or radiation. The idea of using harmful ionizing radiation is to damage and kill cancer cells, preventing their further division and growth. However, ionizing radiation, that is, radiation that destroys cellular DNA, does not discriminate between healthy and cancerous tissues, and as such there is always ‘collateral damage’ that burns otherwise healthy skin and other cells in the path of the exposure. The goal of an oncologist using radiation is to minimize the damage done to healthy tissue and to maximize the damage to cancerous ones.

Disease Classification

Condition: Radiation sickness
Disease Family:
Organ System: Integumentary System
ICD-10 Chapter: Injury, poisoning and certain other consequences of external causes
ICD-10 Code: Y84.2

Radiation-induced adverse effects Symptoms:

Symptoms of adverse effects can vary greatly depending on tissues sites affected, but commonly include severe burns, severe fatigue, lethargy, nausea and vomiting, pain, or inflammation, for instance.

Also known as:

Radiation injury, effect of radiation treatment, effect of radiation therapy, adverse effects of radiation therapy, radiation exposure, abnormal reaction to radiotherapy, abnormal reaction to medical radiotherapy, radiation sickness, radionecrosis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.