Suicide Attempt – Cannabis THC : CBD Ratios

Suicide Attempt Research Dashboard

15

Primary Studies

2

Related Studies

17

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

15

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 17 studies associated with Suicide Attempt.

Here is a small sampling of Suicide Attempt studies by title:


Components of the Suicide Attempt Research Dashboard

  • Dosing information available for Suicide Attempt
  • Chemotype guidance for treating Suicide Attempt with cannabis
  • Synopsis of cannabis research for Suicide Attempt
  • Individual study details for Suicide Attempt

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Overview - Suicide Attempt

Description of Suicide Attempt

While there are a great number of very specific and personal stories (individual motivations) for committing suicide there are also social factors that almost always apply and which were first posited by Émile Durkheim a French sociologist who published the now classical text (Le Suicide)1in 1897 that is still informing today’s students of sociology, psychology, and psychiatry alike. In it he argues that suicides have social and not just psychological causes and that a degree of social disconnection and lack of social belonging is in direct relationship to the degree of suicidal motivations. In other words, groups of people whether organized in families, tribes, by religion, organization, or societal institution in large that are successful in integrating individuals, by providing a sense of belonging and meaningful relationships have a significantly lower rate of self-harming behavior such as suicide. With that in mind consider this: of those veterans in the U.S. who were laid to rest in the years from 2001-2007 roughly one in five committed suicide (deployed 21.3%, non-deployed 19.7%). Within the orthodox consensus the connection between suicidal ideation or behavior is primarily associated with conditions such as anxiety or depression for example and treated accordingly with psycho-pharmaceuticals. Little attention is paid to societal conditions or their mental-emotional impact.

Disease Classification

Condition: Suicide Attempt
Disease Family:
Organ System: Mental/Emotional System
ICD-10 Chapter: Injury, Poisoning and Certain Other Consequences of External Causes
ICD-10 Code: T14.91

Suicide Attempt Symptoms:

Moodswings, an underlying mental condition such as anxiety (PTSD), depression, psychosis for example; expressions of hopelessness, planning or getting the means to commit suicide, expressing the wish to commit suicide, alienation, lack of meaningfull connections, desire to punish other with self-harm

Also known as:

Attempted Suicide

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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