Stroke/Cerebral Infarction – Cannabis THC : CBD Ratios

Stroke/Cerebral Infarction Research Dashboard

37

Primary Studies

15

Related Studies

52

Total Studies

Clinical Studies

1

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

8

Meta-analyses/Reviews

26

Animal studies

2

Laboratory studies

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CannaKeys has 52 studies associated with Stroke/Cerebral Infarction.

Here is a small sampling of Stroke/Cerebral Infarction studies by title:


Components of the Stroke/Cerebral Infarction Research Dashboard

  • Dosing information available for Stroke/Cerebral Infarction
  • Chemotype guidance for treating Stroke/Cerebral Infarction with cannabis
  • Synopsis of cannabis research for Stroke/Cerebral Infarction
  • Individual study details for Stroke/Cerebral Infarction

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Overview - Stroke/Cerebral Infarction

Description of Stroke/Cerebral Infarction

A stroke (cerebrovascular accident or CVA) is a loss of brain function. There are two types of strokes: ischemic and hemorrhagic. In an ischemic stroke, an obstruction (thrombosis, embolism) prevents blood from reaching the brain cells on the other side of the obstruction; thus, it blocks oxygen and may cause tissue damage or death. A hemorrhagic stroke, which results from a ruptured blood vessel causing blood leakage, produces the same consequences.

Disease Classification

Condition: Stroke
Disease Family: Trauma
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Circulatory System
ICD-10 Code: I63

Stroke/Cerebral Infarction Symptoms:

Altered level of consciousness, aphasia, one-sided weakness (e.g. facial droop, one extremity weak or flaccid), unequal pupil size, ataxia, nausea/vomiting

Also known as:

CVA, TIA, Cerebral infarction, cerebrovascular accident

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.