Sleep Apnea – Cannabis THC : CBD Ratios

Sleep Apnea Research Dashboard

7

Primary Studies

0

Related Studies

7

Total Studies

Clinical Studies

2

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

2

Animal studies

0

Laboratory studies

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CannaKeys has 7 studies associated with Sleep Apnea.

Here is a small sampling of Sleep Apnea studies by title:


Components of the Sleep Apnea Research Dashboard

  • Dosing information available for Sleep Apnea
  • Chemotype guidance for treating Sleep Apnea with cannabis
  • Synopsis of cannabis research for Sleep Apnea
  • Individual study details for Sleep Apnea

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Overview - Sleep Apnea

Description of Sleep Apnea

Chronic sleep apnea is characterized by pauses in between breath or by shallow respirations both of which reduce oxygenation to the body's tissue increasing the risk of poor perfusion conditions such as heart attacks or stroke for example. Common culprits are considered to be obstruction from over-weight, family history, or small upper airways for example. Most people don't know they have sleep apnea unless a family member observes the symptoms while they are sleeping. Sleep apnea test can be performed in a laboratory overnight. Treatment options include diet, external breathing devices, mouth pieces, or surgery.

Disease Classification

Condition: Sleep Apnea
Disease Family: Health and Well Being
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G47.3

Sleep Apnea Symptoms:

Long pauses in between breaths while sleeping, shallow breaths, morning drowsiness, poor memory, poor concentration, loud snoring, mood swings

Also known as:

SA, Primary central sleep apnea, High altitude periodic breathing, Obstructive sleep apnea, Congenital central alveolar hypoventilation syndrome

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.