Sepsis – Cannabis THC : CBD Ratios

Sepsis Research Dashboard

13

Primary Studies

5

Related Studies

18

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

4

Meta-analyses/Reviews

8

Animal studies

1

Laboratory studies

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CannaKeys has 18 studies associated with Sepsis.

Here is a small sampling of Sepsis studies by title:


Components of the Sepsis Research Dashboard

  • Dosing information available for Sepsis
  • Chemotype guidance for treating Sepsis with cannabis
  • Synopsis of cannabis research for Sepsis
  • Individual study details for Sepsis

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Overview - Sepsis

Description of Sepsis

Sepsis is a potentially life-threatening condition in which the body's immune system turns on its own cells, tissues, and organs causing potentially irreparable damage. The primary underlying culprits include pathogen induced infections from bacteria, viruses, or other microbes. Sepsis has a biphasic pathology, which based on current thinking begins with an early hyper-inflammatory (over active innate immune response) response to pathogens, which is than followed by the later anti-inflammatory stage in which patients have a suppressed immune response allowing for potentially deadly microbial damage affecting patient's organs. Sepsis is the main reason for death associated with acute kidney failure. Treatment options include IV-fluid replacements and supplemental oxygen to counteract low blood pressure and poor tissue perfusion respectively. It also includes a great number of other supportive measures such as anti-microbial therapies, pharmaceutical drugs to increase blood pressure and immunosuppressive agents for example.

Disease Classification

Condition: Sepsis
Disease Family: Infectious Disease
Organ System: Immune System
ICD-10 Chapter: Certain Infectious and Parasitic Diseases
ICD-10 Code: A41

Sepsis Symptoms:

Fever, tachycardia, rapid respiratory rate, altered mental status, cloudy urine, shock (inadequate tissue perfusion)

Also known as:

Sepsis, Septicaemia

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.