Myasthenia Gravis and Myonerual Disorders – Cannabis THC : CBD Ratios

Myasthenia Gravis and Myonerual Disorders Research Dashboard

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CannaKeys has 3 studies associated with Myasthenia Gravis and Myonerual Disorders.

Here is a small sampling of Myasthenia Gravis and Myonerual Disorders studies by title:


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  • Chemotype guidance for treating Myasthenia Gravis and Myonerual Disorders with cannabis
  • Synopsis of cannabis research for Myasthenia Gravis and Myonerual Disorders
  • Individual study details for Myasthenia Gravis and Myonerual Disorders

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Overview - Myasthenia Gravis and Myonerual Disorders

Description of Myasthenia Gravis and Myonerual Disorders

The term is borrowed from Greek words. 'Mys' meaning muscle, 'an' not, 'aesthesia' sensation, and 'gravis' serious. Putting it all word together you get 'serious no muscle sensation.' Myasthenia Gravis is a chronic degenerative autoimmune and neuromuscular condition that is characterized by the weakening of skeletal muscles. The body's own immune system attacks nicotinic acetylcholine receptors responsible for proper nerve to muscle communication and coordination. The disease usually starts at the facial muscles. There is no cure within orthodox medicine and treatment consists of drugs (e.g. acetylcholinesterase inhibitors, steroids) and controversial surgery (removal of the thymus as a prophylactic measure to prevent thymus cancer).

Disease Classification

Condition: Myasthenia Gravis
Disease Family: Neuromuscular disease
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G70

Myasthenia Gravis and Myonerual Disorders Symptoms:

Droopy facial muscles, aphasia (difficulty talking), ataxia (inability to walk)

Also known as:

MG, Toxic myoneural disorders, Congenital and developmental myasthenia, Lambert-Eaton syndrome,

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.