Motion Sickness – Cannabis THC : CBD Ratios

Motion Sickness Research Dashboard

2

Primary Studies

0

Related Studies

2

Total Studies

Clinical Studies

0

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

1

Animal studies

0

Laboratory studies

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CannaKeys has 2 studies associated with Motion Sickness.

Here is a small sampling of Motion Sickness studies by title:


Components of the Motion Sickness Research Dashboard

  • Dosing information available for Motion Sickness
  • Chemotype guidance for treating Motion Sickness with cannabis
  • Synopsis of cannabis research for Motion Sickness
  • Individual study details for Motion Sickness

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Overview - Motion Sickness

Description of Motion Sickness

Seasickness, airsickness, and carsickness are associated with nausea, vomiting, dizziness, and vertigo. Motion sickness occurs due to discord between the movements perceived by the eyes versus those perceived by the inner ear. If this conflict finds no resolution, nausea may progress to vomiting. An estimated 7% to 28% of travelers experience acute motion sickness.

Disease Classification

Condition: Motion Sickness
Disease Family: Neurological Condition
Organ System: Nervous System
ICD-10 Chapter: Injury, Poisoning and Certain Other Consequences of External Causes
ICD-10 Code: T75.3

Motion Sickness Symptoms:

Dizzyness, vertigo, lack of appetite, nausea, vomiting, generalized weakness

Also known as:

Airsickness, Travel Sickness, Seasickness, Car Sickness, Mal de Mar

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.