Male Infertility – Cannabis THC : CBD Ratios

Male Infertility Research Dashboard

8

Primary Studies

0

Related Studies

8

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

6

Meta-analyses/Reviews

0

Animal studies

2

Laboratory studies

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CannaKeys has 8 studies associated with Male Infertility.

Here is a small sampling of Male Infertility studies by title:


Components of the Male Infertility Research Dashboard

  • Dosing information available for Male Infertility
  • Chemotype guidance for treating Male Infertility with cannabis
  • Synopsis of cannabis research for Male Infertility
  • Individual study details for Male Infertility

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Overview - Male Infertility

Description of Male Infertility

Male infertility simply means the male is unable to produce off spring through intercourse. A majority of causes of male infertility are still subject to ongoing investigation but some of the known factors include endocrine dysfunction, sexually transmitted diseases, traumatic injuries to the testes, urinary tract infections, exposure to environmental toxins (e.g. ionizing radiation, heavy metals, pesticides), chronic medical conditions (e.g. celiac disease), significant or chronic stress, various pharmaceutical medications (e.g. chemotherapies), sperm transport disorders, genetic disorders, or sperm abnormalities for instance. Significant contributing or causative factors also include depression, chronic use of tobacco, alcohol, recreational drugs (e.g. methamphetamines), or steroids for example.

Disease Classification

Condition: Male Infertility
Disease Family: Urological or Endocrine Disorder
Organ System: Reproductive System
ICD-10 Chapter: Diseases of the Genitourinary System
ICD-10 Code: N46

Male Infertility Symptoms:

Sexual dysfunction, low sperm count, low libido

Also known as:

Azoospermia, Oligospermia

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.