Malaria – Cannabis THC : CBD Ratios

Malaria Research Dashboard

7

Primary Studies

7

Related Studies

14

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

3

Animal studies

4

Laboratory studies

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CannaKeys has 14 studies associated with Malaria.

Here is a small sampling of Malaria studies by title:


Components of the Malaria Research Dashboard

  • Dosing information available for Malaria
  • Chemotype guidance for treating Malaria with cannabis
  • Synopsis of cannabis research for Malaria
  • Individual study details for Malaria

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Overview - Malaria

Description of Malaria

Malaria is a worldwide tropical disease that puts at risk about half the world's population with the poorest nations being the most vulnerable. To make matters worse malaria is growing resistant to the available drugs. It is estimated that each year 350 to 500 million cases of malaria occur worldwide, and it is further estimated that of those between one to three million people die, most of them young children. The vast majority of malaria and malaria deaths occurs in sub-Saharan Africa followed at a distance by India and Brazil. The body's immune system initiates complex and strong response such as malarias' characteristic high fevers and chills. Many of the cyclical phases the disease engenders are poorly understood. This is especially true with the most severe form of the illness, cerebral malaria (where the brain is undergoing sudden and severe changes).

Disease Classification

Condition: Malaria
Disease Family: Infectious Disease (Parasite)
Organ System: Immune System
ICD-10 Chapter: Certain Infectious and Parasitic Diseases
ICD-10 Code: B50-B54

Malaria Symptoms:

Cyclical fever, alternating feeling hot (sweating) and cold (shivering), muscular-skeletal pains, headaches, nausea/vomiting, anemia, severe symptoms include sepsis, seizures, altered or loss of consciousness, coma

Also known as:

Plasmodium ovale malaria, Plasmodium malariae malaria, Plasmodium vivax malaria, Plasmodium falciparum malaria

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.