Lupus – Cannabis THC : CBD Ratios

Lupus Research Dashboard

3

Primary Studies

4

Related Studies

7

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

0

Animal studies

1

Laboratory studies

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CannaKeys has 7 studies associated with Lupus.

Here is a small sampling of Lupus studies by title:


Components of the Lupus Research Dashboard

  • Dosing information available for Lupus
  • Chemotype guidance for treating Lupus with cannabis
  • Synopsis of cannabis research for Lupus
  • Individual study details for Lupus

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Overview - Lupus

Description of Lupus

Lupus aka systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which the immune system attacks its own cells and by extension its own organ (organ systems) such as skin, heart, brain, lungs, liver, kidneys or the blood for example resulting in inflammation and damage of the affected tissues. The cause(s) that may trigger the condition is poorly understood and still subject to on-going investigation. Lupus is a chronic condition that occurs with fluctuating intensities and intervals (flare-ups). Orthodox medicine considers hormonal and/or hereditary components, exposure to environmental toxins (e.g. excess UV-light, pharmaceutical drugs such as antibiotics), deficiencies (e.g. vitamin D) or infections as potential causes or contributing factors. SLE tends to occur in significantly higher proportion in women of child-bearing age. Lupus is notoriously difficult to diagnose since patients can represent very different from each other.

Disease Classification

Condition: Lupus
Disease Family: Autoimmune Disorder
Organ System: Immune System
ICD-10 Chapter: Diseases of the Musculoskeletal System and Connective Tissue
ICD-10 Code: M32

Lupus Symptoms:

Generalized weakness, fever, painfully swollen joints, swollen lymph nodes, red rash (e.g. "butterfly" rash on face), dry eyes, photophobia (overly sensitive to light), shortness of breath, chest pain, mild cognitive dysfunction (e.g. memory loss, confusion)

Also known as:

Systemic lupus erythematosus, SLE

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.