Injury Immunodeficiency – Cannabis THC : CBD Ratios

Injury Immunodeficiency Research Dashboard

3

Primary Studies

1

Related Studies

4

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

1

Animal studies

0

Laboratory studies

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CannaKeys has 4 studies associated with Injury Immunodeficiency.

Here is a small sampling of Injury Immunodeficiency studies by title:


Components of the Injury Immunodeficiency Research Dashboard

  • Dosing information available for Injury Immunodeficiency
  • Chemotype guidance for treating Injury Immunodeficiency with cannabis
  • Synopsis of cannabis research for Injury Immunodeficiency
  • Individual study details for Injury Immunodeficiency

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Overview - Injury Immunodeficiency

Description of Injury Immunodeficiency

In trauma-induced immunodeficiency syndrome a significant portion of the central nervous system sustained injury from trauma, stroke, or spinal cord injury for example, which in turn can increase vulnerability to develop infections. CNS-based injury can disturb the critical balance between the immune system and the central nervous system which in turn can result in a weakened immune system and resulting infections such as pneumonia for example. Indeed, infections are a lead cause of death for patients with CNS Injury-Induced Immunodeficiency Syndrome. CNS injury negatively effects cell-based immunity via three major pathways of neuroimmunomodulation: the hypothalamus–pituitary–adrenal axis, the sympathetic, and parasympathetic nervous systems.

Disease Classification

Condition: Injury Immunodeficiency
Disease Family: Nervous System Disorder
Organ System: Immune System, Nervous System
ICD-10 Chapter: Certain disorders involving the immune mechanism
ICD-10 Code: D89.9

Injury Immunodeficiency Symptoms:

Impaired immune responses, endotoxemia (endotoxins aka lipopolysaccharides or LPS produced by gram positive bacteria), cerebral hypoxia-ischemia, oxidative stress, can lead to sepsis, septic shock.

Also known as:

CNS Injury-Induced Immunodeficiency Syndrome, central nervous system injury-induced immune deficiency syndrome.

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.