Hypertension and Hypertensive Diseases – Cannabis THC : CBD Ratios

Hypertension and Hypertensive Diseases Research Dashboard

21

Primary Studies

10

Related Studies

31

Total Studies

Clinical Studies

1

Double-blind human trials

3

Clinical human trials

Pre-Clinical Studies

2

Meta-analyses/Reviews

13

Animal studies

2

Laboratory studies

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CannaKeys has 31 studies associated with Hypertension and Hypertensive Diseases.

Here is a small sampling of Hypertension and Hypertensive Diseases studies by title:


Components of the Hypertension and Hypertensive Diseases Research Dashboard

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  • Chemotype guidance for treating Hypertension and Hypertensive Diseases with cannabis
  • Synopsis of cannabis research for Hypertension and Hypertensive Diseases
  • Individual study details for Hypertension and Hypertensive Diseases

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Overview - Hypertension and Hypertensive Diseases

Description of Hypertension and Hypertensive Diseases

According to modern medicine, “normal” pressure is 120/80. However, optimal pressure is not clearly defined. Some people are happy and healthy with either lower or slightly higher numbers. However, The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure suggests that: “The risk of coronary vascular disease, beginning at 115/75 mm Hg, doubles with each increment of 20/10 mm Hg.” Observable mental-emotional and physical co-factors include family history, obesity, poor diet, smoking, alcohol abuse, physical inactivity, arteriosclerosis (hardening of the arteries), age, chronic stress, depression, anxiety, insulin resistance, and diabetes. Orthodox treatment is limited to lifelong pharmaceutical management and intervention during acute phases.

Disease Classification

Condition: Hypertension
Disease Family: Cardiovascular Disease
Organ System: Cardiovascular System
ICD-10 Chapter: Diseases of the Circulatory System
ICD-10 Code: I10-I16

Hypertension and Hypertensive Diseases Symptoms:

Many patients are asymptomatic, blood pressure is elevated (the risk of coronary vascular disease, beginning at 115/75 mm Hg, doubles with each increment of 20/10 mm Hg), eventual symptoms may include: dizzyness, headache, blurred vision, nausea and vomiting.

Also known as:

HTN, Hypertensive heart disease, Hypertensive chronic kidney disease, Secondary hypertension, Hypertensive crisis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.