Heart Attack – Cannabis THC : CBD Ratios

Heart Attack Research Dashboard

10

Primary Studies

7

Related Studies

17

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

5

Meta-analyses/Reviews

4

Animal studies

1

Laboratory studies

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CannaKeys has 17 studies associated with Heart Attack.

Here is a small sampling of Heart Attack studies by title:


Components of the Heart Attack Research Dashboard

  • Dosing information available for Heart Attack
  • Chemotype guidance for treating Heart Attack with cannabis
  • Synopsis of cannabis research for Heart Attack
  • Individual study details for Heart Attack

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Overview - Heart Attack

Description of Heart Attack

The heart is a unique muscle that gets its own nourishment from three main vessels called the coronary arteries. In Western medicine’s model, when one or more of these coronary arteries is slowly or suddenly blocked (as in the case of a blood clot) or gradually narrows (as in the case of atherosclerosis, a build-up of plaque), the heart muscle begins to ache. If not corrected, this “ache” can progress to tissue death called a myocardial infarction or heart attack. The size of the infarct determines survivability. Other common causes of damaged hearts or contributing factors include high blood pressure, metabolic syndrome (insulin resistance), excess weight, drug use (especially “uppers” such as cocaine, crack, methamphetamines), stress (especially chronic stress), mineral imbalances, pharmaceutical drugs including those designed to prevent irregular heartbeats, surgical procedures such as bypass or angioplasty, build-up of toxins (such as lead, mercury, etc.), and degeneration from chronic overexposure to free radicals. Whatever the underlying sudden or chronic cause for acute heart pain, in orthodox medicine it boils down to a lack of oxygen. Allopathic treatments include supplemental oxygen, pharmaceuticals, emergency interventions, and surgery.

Disease Classification

Condition: Heart Attack
Disease Family:
Organ System: Cardiovascular System
ICD-10 Chapter: Diseases of the Circulatory System
ICD-10 Code: I21

Heart Attack Symptoms:

Chest pain (e.g. pressure, radiating down left arm), shortness of breath, pale and clammy skin, irregular heartbeat, nausea/vomiting, confusion, loss of consiousness

Also known as:

Myocardial Infarction, Coronary Embolism, Coronary Thrombosis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.