Gastro-Esophageal Reflux Disease – Cannabis THC : CBD Ratios

Gastro-Esophageal Reflux Disease Research Dashboard

6

Primary Studies

1

Related Studies

7

Total Studies

Clinical Studies

1

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

3

Meta-analyses/Reviews

2

Animal studies

0

Laboratory studies

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CannaKeys has 7 studies associated with Gastro-Esophageal Reflux Disease.

Here is a small sampling of Gastro-Esophageal Reflux Disease studies by title:


Components of the Gastro-Esophageal Reflux Disease Research Dashboard

  • Dosing information available for Gastro-Esophageal Reflux Disease
  • Chemotype guidance for treating Gastro-Esophageal Reflux Disease with cannabis
  • Synopsis of cannabis research for Gastro-Esophageal Reflux Disease
  • Individual study details for Gastro-Esophageal Reflux Disease

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Overview - Gastro-Esophageal Reflux Disease

Description of Gastro-Esophageal Reflux Disease

Commonly known as heartburn and acid reflux disease, this illness is due to damage of the esophageal mucous membrane and the esophageal sphincter. Damage occurs when stomach acid reaches the lower part of the esophagus. Under normal conditions, the esophageal sphincter opens to allow food and drink to enter the stomach but closes right after to prevent stomach acid from affecting the tissue above. In GERD, however, the closing action is temporarily incomplete, allowing acid to reach unprotected tissue and cause damage. This mechanism is also referred to as transient lower esophageal sphincter relaxations. GERD-produced damage can lead to long-term problems and acute episodes. Allopathic treatments include pharmaceuticals and surgery, each with their own risks and side effects.

Disease Classification

Condition: Gastro-Esophageal Reflux
Disease Family: Gastrointestinal Disorder
Organ System: Digestive System
ICD-10 Chapter: Diseases of the Digestive System
ICD-10 Code: K21

Gastro-Esophageal Reflux Disease Symptoms:

Heartburn (worse lying down), regurgitation, increased saliva production

Also known as:

GERD

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.