Fungal Infections – Cannabis THC : CBD Ratios

Fungal Infections Research Dashboard

12

Primary Studies

2

Related Studies

14

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

0

Meta-analyses/Reviews

2

Animal studies

10

Laboratory studies

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CannaKeys has 14 studies associated with Fungal Infections.

Here is a small sampling of Fungal Infections studies by title:


Components of the Fungal Infections Research Dashboard

  • Dosing information available for Fungal Infections
  • Chemotype guidance for treating Fungal Infections with cannabis
  • Synopsis of cannabis research for Fungal Infections
  • Individual study details for Fungal Infections

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Overview - Fungal Infections

Description of Fungal Infections

Mycosis is the term used to describe a pathogenic fungal infection in mammalian bodies. Among a great many types of harmful fungi one of the more common ones is C. albicans, a fungal infection that can manifest symptoms locally on mucosal membranes such as the mouth or the genitals for instance. A more serious form of C. albicans infections can occur systemically especially in individuals with lowered immunity such as patients undergoing chemotherapy, AIDS, or organ transplants). Systemic C. albicans can be fatal. Pharmaceutical intervention is limited in their success but include a small number of antifungal agents.

Disease Classification

Condition: Fungal Infections
Disease Family: Infectious Disease (Fungus)
Organ System: Digestive System, Integumentary System
ICD-10 Chapter: Certain Infectious and Parasitic Diseases
ICD-10 Code: B35-B49

Fungal Infections Symptoms:

Symptoms depend of type of fungus and location affected. Candida albicans infection: itching, irritation, soreness, pain, thrush (mucus memberanes of the mouth, vagina, penile, anal), discharge, bloating, flatulence, abdominal discomforts, chronically weak, moody, brain fog

Also known as:

Candida Albicans, Dermatophytosis, Mycosis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.