Fatty Liver Disease – Cannabis THC : CBD Ratios

Fatty Liver Disease Research Dashboard

14

Primary Studies

10

Related Studies

24

Total Studies

Clinical Studies

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

7

Meta-analyses/Reviews

5

Animal studies

2

Laboratory studies

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CannaKeys has 24 studies associated with Fatty Liver Disease.

Here is a small sampling of Fatty Liver Disease studies by title:


Components of the Fatty Liver Disease Research Dashboard

  • Dosing information available for Fatty Liver Disease
  • Chemotype guidance for treating Fatty Liver Disease with cannabis
  • Synopsis of cannabis research for Fatty Liver Disease
  • Individual study details for Fatty Liver Disease

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Overview - Fatty Liver Disease

Description of Fatty Liver Disease

There are two broad categories of fatty liver disease aka hepatic steatosis i.e. alcoholic fatty liver disease and non-alcoholic fatty liver disease (NAFLD) the latter of which express as two types non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). NAFL tends to be on the more benign side while NASH typically includes inflammation and when left unchecked and untreated may progress to the development of fibrosis, cirrhosis, esophageal varices, and liver cancer for example. In general, fatty liver disease is considered a chronic condition characterized by excess fat build up in the liver. Many times, the patient will be present in an asymptomatic and if symptoms occur, they may include only mild forms of right upper quadrant pain, pressure, combined with an increased and generalized weakness. Orthodox medicine suggests a number of contributing factors in its underlying pathologies such as obesity (hyperlipidemia, metabolic syndrome), alcoholism, poor nutrition, diabetes, hepatitis C, hypertension, inflammatory bowel disease, the use of certain pharmaceutical (e.g. steroids, antiviral drugs) for example.

Disease Classification

Condition: Fatty Liver Disease
Disease Family: Fatty Liver disease
Organ System: Digestive System
ICD-10 Chapter: Diseases of the Digestive System
ICD-10 Code: K76.0

Fatty Liver Disease Symptoms:

Enlarged liver, upper right abdominal discomfort/pain, generalized weakness, jaundice, ascites, male breast development, red palms, obesity, metabolic syndrome

Also known as:

FLD, NAFLD, Hepatic Steatosis

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.