Constipation – Cannabis THC : CBD Ratios

Constipation Research Dashboard

3

Primary Studies

0

Related Studies

3

Total Studies

Clinical Studies

0

Double-blind human trials

2

Clinical human trials

Pre-Clinical Studies

1

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 3 studies associated with Constipation.

Here is a small sampling of Constipation studies by title:


Components of the Constipation Research Dashboard

  • Dosing information available for Constipation
  • Chemotype guidance for treating Constipation with cannabis
  • Synopsis of cannabis research for Constipation
  • Individual study details for Constipation

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Overview - Constipation

Description of Constipation

While constipation is usually not consider a condition but rather a symptoms it is common enough to warrant inclusion. Constipation is the difficulty of, or the too infrequent passing of stool. There are a number of common contributing causes that include life-styles (e.g. sedentary, lack of hydration, lack of fiber diet), underlying conditions (e.g. hypothyroidism, inflammatory bowel disease) or certain classes of pharmaceutical drugs (e.g. opioids, anticholinergics, calcium channel blockers) for example. Complications from constipation include hemorrhoids, anal fissures, bowel impaction, and vasovagal responses.

Disease Classification

Condition: Constipation
Disease Family: Gastrointestinal Disorder
Organ System: Digestive System
ICD-10 Chapter: Diseases of the Digestive System
ICD-10 Code: K59

Constipation Symptoms:

Hard and dry bowel content. Straining or struggling when bearing down to pass stool, abdominal pain or pressure, and feeling of incomplete voids.

Also known as:

Obstipation, Infrequent bowel movements

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.