Cognitive Dysfunction – Cannabis THC : CBD Ratios

Cognitive Dysfunction Research Dashboard

45

Primary Studies

30

Related Studies

75

Total Studies

Clinical Studies

4

Double-blind human trials

3

Clinical human trials

Pre-Clinical Studies

21

Meta-analyses/Reviews

15

Animal studies

1

Laboratory studies

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CannaKeys has 75 studies associated with Cognitive Dysfunction.

Here is a small sampling of Cognitive Dysfunction studies by title:


Components of the Cognitive Dysfunction Research Dashboard

  • Dosing information available for Cognitive Dysfunction
  • Chemotype guidance for treating Cognitive Dysfunction with cannabis
  • Synopsis of cannabis research for Cognitive Dysfunction
  • Individual study details for Cognitive Dysfunction

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Overview - Cognitive Dysfunction

Description of Cognitive Dysfunction

In its most basic ways cognitive functions are defined as the ability to perceive, think, discern, imagine, and remember. There is not one size fits all version of cognitive decline. Age-related changes in cognition can occur in each and all of the broad categories mentioned above. Reasons for cognitive decline are poorly understood but are thought to include one or a combination of a numerous factors such as physical or mental-emotional trauma, a lack of proper nutrition, chronic or acute stress, lack of sleep, the presence of toxins, and acute or chronic physical or mental illnesses for example.

Disease Classification

Condition: Cognitive Dysfunction
Disease Family: Neurological Disease, Mental Disorder
Organ System: Nervous System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G31.84

Cognitive Dysfunction Symptoms:

Forgetful, losing things, easily overwhelmed when faced with simple tasks, friends notice changes

Also known as:

Learning and Memory Problems, Mild neurocognitive disorder, Mild Cognitive Impairment, Memory Loss, Cognitive Decline

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.