Brachial Plexus Disorders – Cannabis THC : CBD Ratios

Brachial Plexus Disorders Research Dashboard

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Double-blind human trials

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CannaKeys has 1 studies associated with Brachial Plexus Disorders.

Here is a small sampling of Brachial Plexus Disorders studies by title:


Components of the Brachial Plexus Disorders Research Dashboard

  • Dosing information available for Brachial Plexus Disorders
  • Chemotype guidance for treating Brachial Plexus Disorders with cannabis
  • Synopsis of cannabis research for Brachial Plexus Disorders
  • Individual study details for Brachial Plexus Disorders

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Overview - Brachial Plexus Disorders

Description of Brachial Plexus Disorders

This type of condition results from trauma to the brachial plexus, a cluster of nerves that connect between the spinal cord from the lower cervical to the upper thoracic vertebrae to the hand, arm, chest and shoulder. Avulsion refers to a tear-like injury, at the base of the brachial plexus is a significantly painful injury that can take years to heal. It is usually accompanied by severe pains that don't tend to respond very well to opioids, anticonvulsants and tricyclic antidepressants frequently used to treat this type of central neuropathic pain syndrome.

Disease Classification

Condition: Brachial Plexus Disorders
Disease Family: Trauma
Organ System: Muscular System
ICD-10 Chapter: Diseases of the Nervous System
ICD-10 Code: G54.0

Brachial Plexus Disorders Symptoms:

Pain (hot, electric), weak and numbness, frozen limb, neck pain

Also known as:

BPI, Brachial Plexus Avulsion, Brachial plexus disorder,

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.