Bipolar Affective Disorder – Cannabis Research

Bipolar Affective Disorder Research Dashboard


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CannaKeys has 36 studies associated with Bipolar Affective Disorder.

Here is a small sampling of Bipolar Affective Disorder studies by title:

Components of the Bipolar Affective Disorder Research Dashboard

  • Dosing information available for Bipolar Affective Disorder
  • Chemotype guidance for treating Bipolar Affective Disorder with cannabis
  • Synopsis of cannabis research for Bipolar Affective Disorder
  • Individual study details for Bipolar Affective Disorder

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Overview - Bipolar Affective Disorder

Description of Bipolar Affective Disorder

Psychiatry considers bipolar or manic-depressive disorder to be a chronic mental illness characterized by dramatic and sudden mood swings ranging from manic to depressed and back. Onset of the illness is usually observed in late adolescence or early adulthood but has also been noted in younger people. While normal ups and downs in mood are part of being human, pathological mood swings severely reduce quality of life, ability to function and to maintain social relations. Subgroups of the illness are identified on a spectrum by severity of the disease and frequency of mood swings. The scientific community believes that bipolar disorders have a variety of causes. Origins could be genetic, environmental (childhood trauma or abuse), or physiological (e.g., brain, endocrine irregularities). Diagnosis is based on observation and clinical evaluation. Tests may be performed to rule out possible underlying causes or contributing diseases. Western treatment consists of pharmacological interventions and talk therapy. The most commonly used pharmaceutical is an alkali metal lithium which functions as a potent mood stabilizer and has been proven to significantly prevent suicides in bipolar patients.

Disease Classification

Condition: Bipolar Disorder
Disease Family: Mental-Emotional Disorder
Organ System: Mental/Emotional System, Nervous System
ICD-10 Chapter: Mental and Behavioural Disorders
ICD-10 Code: F31

Bipolar Affective Disorder Symptoms:

Cyclical mania-depression, rapid mood swings, behavioral difficulties (e.g. poor impulse control, aggessive behavior), psychosis (e.g. hallucinations), sleep disturbances (e.g. too much or too little sleep),

Also known as:

BAD, Manic-depressive illness, Manic-depressive psychosis, Manic-depressive reaction

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.