Anorexia Nervosa – Cannabis Research

Anorexia Nervosa Research Dashboard

32

Primary Studies

19

Related Studies

51

Total Studies

Clinical Studies

1

Clinical Meta-analyses

4

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

19

Meta-analyses/Reviews

7

Animal studies

0

Laboratory studies

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CannaKeys has 51 studies associated with Anorexia Nervosa.

Here is a small sampling of Anorexia Nervosa studies by title:


Components of the Anorexia Nervosa Research Dashboard

  • Dosing information available for Anorexia Nervosa
  • Chemotype guidance for treating Anorexia Nervosa with cannabis
  • Synopsis of cannabis research for Anorexia Nervosa
  • Individual study details for Anorexia Nervosa

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Overview - Anorexia Nervosa

Description of Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric disorder characterized by an underlying fear of becoming fat or a person’s pathological obsession with losing weight. It is associated with a relatively high mortality rate and evidence-based and effective treatment is largely wanting. While the precise mechanisms of AN is subject to ongoing scientific exploration it is posited to arise from a combination of chronic genetic, behavioural, emotional, psychological, interpersonal, post-traumatic experiences, and other social factors resulting in an insufficient caloric intake. Recent discoveries suggest therapeutic potential associated with interactivities between endocannabinoid, ghrelin and leptin signaling.

Disease Classification

Condition: Anorexia Nervosa
Disease Family:
Organ System: Mental/Emotional System
ICD-10 Chapter: Mental, Behavioral and Neurodevelopmental Disorders
ICD-10 Code: F50.01

Anorexia Nervosa Symptoms:

No appetite, food avoidance, weight loss, severe fear of gaining weight, severe urge to be physically active, emaciation, unhealthy or distorted body image (giving an extreme importance of being skinny), underlying emotional problems, excessive dieting, excessive use of diet pills, laxatives, enemas, or conscious purging after eating, weakness, fatigue, fainting spells, sleep disturbances, dehydration, hypotension, social isolation, flat affect, amenorrhea

Also known as:

Anorexia Nervosa

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), beta-blockers (e.g. propranolol), bronchodilators (e.g. theophylline), or bloodthinners (e.g. warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg
  • THC low dose:  0.5 mg to 5 mg
  • THC medium dose:  6 mg to 20 mg
  • THC high dose:  21 mg to 50+ mg

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg
  • CBD medium dose: 20 mg to 99 mg
  • CBD high dose:  100 mg to 800+ mg (upper limits tested ~1,500mg)
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Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.