Allergies to Cannabis – Cannabis THC : CBD Ratios

Allergies to Cannabis Research Dashboard

20

Primary Studies

0

Related Studies

20

Total Studies

Clinical Studies

0

Double-blind human trials

3

Clinical human trials

Pre-Clinical Studies

17

Meta-analyses/Reviews

0

Animal studies

0

Laboratory studies

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CannaKeys has 20 studies associated with Allergies to Cannabis.

Here is a small sampling of Allergies to Cannabis studies by title:


Components of the Allergies to Cannabis Research Dashboard

  • Dosing information available for Allergies to Cannabis
  • Chemotype guidance for treating Allergies to Cannabis with cannabis
  • Synopsis of cannabis research for Allergies to Cannabis
  • Individual study details for Allergies to Cannabis

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Overview - Allergies to Cannabis

Description of Allergies to Cannabis

Some people are or can become sensitized (i.e. the process of becoming allergic) to cannabis or specific cannabis constituents. In such patients their immune system becomes overly reactive to exposure, which can result in signs and symptoms ranging between very mild (e.g. sneezing) and severe (e.g. anaphylactic reaction). Depending on pathway of sensitization exposure to either airborne allergen via inhalation, topical contact with cannabis, or the ingestion of plant parts can induce pathway specific signs or symptoms (see signs and symptoms). The allergic route via ingestion can also become amplified with common cross-allergic reactions with allergies to vegetables (e.g. tomatoes, eggplant), fruits (e.g. citrus, banana) or nuts (e.g. almonds, chestnuts) for example. In other words if you already have an allergy to any of these foods you may be at higher risk of also being sensitized to cannabis.

Disease Classification

Condition: Cannabis Allergies
Disease Family:
Organ System: Immune System
ICD-10 Chapter: Factors influencing health status and contact with health services
ICD-10 Code: Z88.9

Allergies to Cannabis Symptoms:

Inhalation-based exposure symptoms may include: sneezing, runny nose, swollen, red, teary eyes, burning eyes, itching of nose and eyes, stuffy head, itchy throat, coughing, wheezing and resulting shortness of breath; touch or topical contact-based signs and symptoms may include: itching, reddening of the skin, swelling, developments of rash or hives; ingestion-based signs or symptoms may include: abdominal bloating, pain or diarrhea for example but also manifest as one or a number of signs or symptoms mentioned above.

Also known as:

Occupational allergies to cannabis, cannabis-associated asthma and allergies, cannabis allergies, allergic hypersensitivity to cannabis, marijuana allergy, sensitization to cannabis, sensitization to marijuana

Drug Interactions

THC Interaction with Pharmaceutical Drugs

  • THC can enhance the effects of drugs that cause sedation and depress the central nervous system, such as benzodiazepines, barbiturates, and alcohol, for example. 
  • THC is metabolized by and an inhibitor of a number of enzymatic liver pathways referred to as cytochrome P450. There are more than 50 enzymes belonging to this enzyme family, a number of which are responsible for the breakdown of common drugs such as antidepressants (e.g. amitriptyline, doxepine, fluvoxamine), antipsychotics (haloperidol, clozapine, stelazine), or beta-blockers (propranolol, theophylline, warfarin).  Thus patients taking these classes of medication may find that THC increases the concentration and effects of these drugs as well as the duration of their effects.
  • Clinical observation suggests no likely interactions with other pharmaceuticals at a total daily dose of up to 20mg THC.

CBD Interaction with Pharmaceutical Drugs

  • CBD may alter action on metabolic enzymes (certain drug-transport mechanisms), and as such may alter interactions with other drugs, some of which may produce therapeutic or adverse effects. For instance, CBD interacts with the enzyme cytochrome P450 3A4 and cytochrome P450 2C19, increasing the bioavailability of anti-epileptic drugs such as clobazam (a benzodiazepine). This makes it possible to achieve the same results at significantly lower dosages, reducing treatment costs and risks of adverse effects. 
  • Groups of drugs affected include: anti-epileptic drugs, psychiatric drugs, and drugs affecting metabolic enzymes, for example.
  • Clinical observations suggest no likely interactions with other pharmaceuticals at a total daily dose of up to 100mg CBD

Dosing Considerations

THC Dosage Considerations

  • THC micro dose:  0.1 mg to 0.4 mg (0.001mg/kg to 0.005mg/kg)
  • THC low dose:  0.5 mg to 5 mg (0.006mg/kg to 0.06mg/kg)
  • THC medium dose:  6 mg to 20 mg (0.08mg/kg to 0.27mg/kg)
  • THC high dose:  21 mg to 50+ mg (0.28mg/kg to 0.67mg/kg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)

CBD Dosage Considerations

  • CBD low dose:  0.4 mg to 19 mg (0.005mg/kg to 0.25mg/kg)
  • CBD medium dose: 20 mg to 99 mg (0.26mg/kg to 1.32mg/kg)
  • CBD high dose:  100 mg to 800+ mg (1.33mg/kg to 10.7mg/kg)
  • (upper limits tested ~1,500mg)
Formula for converting a set dose into mg/kg considerations: mg ÷ kg = mg/kg
(sample conversion calculated on a person weighing 75kg)
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.