LPI and 2-ALPI Cannabinoid Research

LPI and 2-ALPI Research Dashboard


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CannaKeys has 17 studies associated with LPI and 2-ALPI.

Here is a small sampling of LPI and 2-ALPI studies by title:

Components of the LPI and 2-ALPI Research Dashboard

  • Top medical conditions associated with LPI and 2-ALPI
  • Proven effects in clinical trials for LPI and 2-ALPI
  • Receptors associated with LPI and 2-ALPI
  • Individual study details for LPI and 2-ALPI

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Overview - LPI and 2-ALPI

Description of LPI and 2-ALPI

LPI is a proposed endogenous ligand/agonist for GPR55 (Roberto Piñeiro et al. 2012)

2-ALPI is a proposed endogenous ligand/agonist for GPR55 (Saori Oka et al. 2009)

Other Names:

Lysophosphatidylinositol and 2-arachidonoyl lysophosphatidylinositol
LPI: L-alpha-lysophosphatidylinositol; L-α-lysophosphatidylinositol

LPI IUPAC Name: [(2S)-2-hydroxy-3-[hydroxy-[(2R,3S,5R,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxypropyl] acetate

LPI Molecular Formula: C11H21O12P

2-ALPI: 2-arachidonoyl-LPI; 2-arachidonoyl-lysophosphatidylinositol; 2-arachidonoyl-sn-glycero-3-phospho-D-myo-inositol 4,5-bisphosphate

2-ALPI IUPAC Name: [(1R,2S,3R,4R,5S,6R)-2,3,5-trihydroxy-4-[[(2R)-3-hydroxy-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxypropoxy]-oxidophosphoryl]oxy-6-phosphonatooxycyclohexyl] phosphate

2-ALPI Molecular Formula: C29H46O18P3-5


LPI and 2-ALPI Properties and Effects

The LPI/GPR55 axis may play a negative role in the pathology of:
• May worsen metabolic disorders (e.g., obesity, diabetes, inflammation)
• May worsen developments and metastasis of certain cancer (e.g., breast cancer, colon cancer, uterine/endometrial cancer)
• May worsen non-alcoholic steatosis & steatohepatitis
• May worsen myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway
• Inflammation (mixed results with some studies suggesting pro- vs anti-inflammatory effects)

Inhibitors of LPI: Δ9-tetrahydrocannabivarin, cannabidivarin, and cannabigerovarin are inhibitors of LPI (Sharon Anavi-Goffer et al. 2012); CBD (E Ryberg et al. 2007)

LPI and 2-ALPI Receptor Binding

Endocannabinoidome (eBCome)
• Both LPI and 2-LPI are proposed endogenous ligand/agonist for GPR55.
• LPI activates TRPV2 (Kazuki Harada et al. 2017)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.