PRIMARY STUDY

The neuroprotection of cannabidiol against MPP(+)-induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease.

Key Findings:  This is the first study to report the involvement of neuronal proteins and nerve growth factor (NGF) receptors (trkA) in the neuroprotection of CBD. Findings suggest that CBD has a neurorestorative potential independent of NGF that might contribute to its neuroprotection against 1-methyl-4-phenylpyridinium iodide [MPP(+)], a neurotoxin relevant to Parkinson's disease.