Key Findings:  The multi-target modulators of ECS could be able to control disease progression, and at the same time the symptoms of multiple sclerosis, and might have a translational potential and could represent promising candidates for clinical development.
Type of Study:  Meta-analysis
Study Result:  Positive
Study Location(s):  Italy
Year of Pub:  2018
Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabinol (THC), JWH-x Synthetic Cannabinoids, O-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids, Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Synthetic Cannabinoid (unspecified), Pharma THC, Pharma THC:CBD, Other Related Compounds
Phytocannabinoid Source:  Not Applicable
Chemotype:  Chemotype I, Chemotype II
Terpenes Studied:  ß-Caryophyllene
Receptors Studied:  CB1, CB2, PPAR - Gamma
Ligands Studied:  Anti-inflammatory cytokines, Glutamate, Pro-inflammatory cytokines