RELATED STUDY
Opioid-Sparing Effect of Cannabinoids: A Systematic Review and Meta-Analysis.
Key Findings: Through meta-analyses, it was found that the doses of morphine and codeine required to produce the same analgesic effect were 3.6 and 9.5 times lower, respectively, when co-administered with delta-9-THC. Most studies (17 of the 19) demonstrated that combining a cannabinoid with an opioid resulted in a synergistic effect on analgesia compared to the analgesic effects of the individual drugs.
Type of Study: Meta-analysis
Study Result: Positive
Study Location(s): Australia, Canada
Year of Pub: 2017
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC), CP-x Synthetic Cannabinoids, HU-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids, Pharma THC, Pharma THC:CBD
Phytocannabinoid Source: Not Applicable
Chemotype: Chemotype I, Chemotype II
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB1, CB2
