Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson’s Disease. Induced by MPTP.

Key Findings:  These results indicate that BCP acts via multiple neuroprotective mechanisms in our murine model and suggest that BCP may be viewed as a potential treatment and/or preventative agent for PD.

Type of Study:  Animal Study

Study Result:  Positive

Cannabinoids Studied:  AM-x Synthetic Cannabinoids

Form of Administration:  Ingestion, Injection

Dosage: BCP (10 mg/kg, i.p. and 10 mg/kg through an oral gavage) for 5 consecutive days. The protective effect of BCP against astrocyte activation and microglia was fully reversed by pre-treating with 3 mg/kg AM630.

Terpenes Studied:  ß-Caryophyllene

Receptors Studied:  CB2

Ligands Studied:  Anti-inflammatory cytokines, Dopamine, Pro-inflammatory cytokines

Study Location(s):  Mexico, Spain, Switzerland

Year of Pub:  2017

Link to study