RELATED STUDY

Raising awareness: The implementation of medical cannabis and psychedelics used as an adjunct to standard therapy in the treatment of advanced metastatic breast cancer

Key Findings:  The authors report the case of a 49-year-old woman with metastasizing breast cancer spreading to the bone, liver, and lymph nodes. She received several rounds of chemotherapy and radiation therapy. In addition, the patient began self-administering cannabis daily in the form of oils and alcohol extracts (containing CBD, CBDA, CBDV, CBC, THC, THCA, THCV, CBG, CBGA, and CBN) as well as psilocybin in four sessions over a period of three years. After five-month of cannabinoid-based treatments imaging showed no evidence of metastatic disease. After 18 months (and reduced cannabinoid-therapy to 60% of peak treatment dosages) the cancer returned. Treatment levels were restored to the initial dosing protocol and 16 months after recurrence, tests revealed the regression of the cancer.

Type of Study:  Meta-analysis

Study Sample Size:  1

Study Result:  Positive

Study Location(s):  United Kingdom, United States

Year of Pub:  2022


Cannabinoids Studied:  Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), Cannabidiolic Acid (CBD-a), Cannabigerolic Acid (CBG-a), Tetrahydrocannabinolic Acid (THC-a), Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV)

Phytocannabinoid Source:  Cannabis Flower derived

DOSING DETAILS   

Study Dosing Objective:  Dosing Protocol Only

Established Protocol:  Effective dose

Route of Administration:  Oral (Ingestion)

Cannabinoid Ratio:  (CBG-A : CBDA : CBD)   3271 : 1752 : 1064    

Dosage Form:  whole plant concentrated extracts

Dosing Regimen:  High-dose protocol of mixed cannabidiol (CBD) and delta9-tetrahydrocannabinol (THC) chemotypes, as well as psilocybin-assisted psychotherapy at macro and intermittent micro-doses

Treatment Duration:  2 years

Clinical Relevance:  The therapeutic adjunctive effect of both psychedelics and cannabis-based medicinal products might provide useful supplementation to standardized chemotherapy and more targeted therapy regimens.

Adverse Events:  No serious adverse events.

Additional Notes:  Pharmacokinetic Study Data



Link to study