PRIMARY STUDY

Effects of non‐euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice

Key Findings:  This study evaluated three cannabinoid compounds and their effects in a model of muscular degeneration. Results show, via the TRP channels in skeletal muscle, CBD, CBDV and THCV have anti-inflammatory activity, prevented loss of locomotor activity, and restored autophagy, suggesting potential therapeutic use in Duchenne muscular dystrophy (DMD).

Type of Study:  Laboratory Study

Study Result:  Positive

Study Location(s):  Italy

Year of Pub:  2018


Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV)

Phytocannabinoid Source:  Unspecified

Receptors Studied:  TRPA1, TRPV1, TRPs

Route of Administration:  In vitro, Injection



Link to study