PRIMARY STUDY

β-caryophyllene ameliorated obesity-associated airway hyperresponsiveness through some non-conventional targets

Key Findings:  Obesity-associated airway hyperresponsiveness is ameliorated by administration of BCP. More specifically, these effects were initiated via the inhibition of macrophage polarization, by activation of AMPKα, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, by up-regulation of adiponectin, GLP-1, IFN-γ, SOD, catalase and by down-regulation of NF-κB, leptin, IL-4, TNF, and IL-1β.

Type of Study:  Animal Study

Study Result:  Positive

Study Location(s):  India

Year of Pub:  2021


Cannabinoids Studied: 

Phytocannabinoid Source:  Not Applicable

Terpenes Studied:  ß-Caryophyllene

Ligands Studied:  Anti-inflammatory cytokines, Pro-inflammatory cytokines