Key Findings:  This review discusses the current body of evidence of the mechanism of action and multiple interactions between phytocannabinoids and the endocannabinoid system, and the promising potential utility of cannabioids in autoimmune disorders, specifically multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis.
Type of Study:  Meta-analysis
Study Result:  Positive
Study Location(s):  Italy
Year of Pub:  2021
Cannabinoids Studied:  Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), N-Arachidonoyl Dopamine (NADA), Virodhamine (O-AEA), Cannabinoid (unspecified), Endocannabinoid (unspecified), Other Related Compounds
Phytocannabinoid Source:  Unspecified
Terpenes Studied:  ß-Caryophyllene, Limonene
Receptors Studied:  CB1, CB2, GPCR 18, GPCR 55, TRPA1, TRPV2, TRPV4, PPAR - Gamma
Ligands Studied:  Glutamate, Pro-inflammatory cytokines