RELATED STUDY

Cannabis and Autoimmunity: Possible Mechanisms of Action

Key Findings:  This review discusses the current body of evidence of the mechanism of action and multiple interactions between phytocannabinoids and the endocannabinoid system, and the promising potential utility of cannabioids in autoimmune disorders, specifically multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis.

Type of Study:  Meta-analysis

Study Result:  Positive

Study Location(s):  Italy

Year of Pub:  2021


Cannabinoids Studied:  Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), N-Arachidonoyl Dopamine (NADA), Virodhamine (O-AEA), Cannabinoid (unspecified), Endocannabinoid (unspecified), Other Related Compounds

Phytocannabinoid Source:  Unspecified

Terpenes Studied:  ß-Caryophyllene, Limonene

Receptors Studied:  CB1, CB2, GPCR 18, GPCR 55, TRPA1, TRPV2, TRPV4, PPAR - Gamma

Ligands Studied:  Glutamate, Pro-inflammatory cytokines