PRIMARY STUDY

Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

Key Findings:  CBD is a very low-affinity agonist at CB1 that can nevertheless affect CB1 receptor activity in vivo in an indirect manner. THCV is a high-affinity antagonist at CB1 in vitro but only occasionally produces effects in vivo. THCV has also high affinity for CB2 receptors and signals as a partial agonist, differing from both CBD and rimonabant.

Type of Study:  Meta-analysis

Study Result:  Positive

Study Location(s):  Italy, United Kingdom

Year of Pub:  2015


Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabivarin (THCV)

Phytocannabinoid Source:  Unspecified

Receptors Studied:  CB1, CB2