PRIMARY STUDY

Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization

Key Findings:  Treatments with CBC + THC or CBD led to cell cycle arrest and cell apoptosis. Synergistic effects were observed between CBC + THC. In direct contrast, inverse agonism of CB1 and CB2 produced cytotoxic activity.