PRIMARY STUDY
The Anti-Inflammatory Properties of Terpenoids from Cannabis
Key Findings: Different chemotypes of cannabis have a distinctive composition of terpenoids. These essential oils do have anti-inflammatory and antinociceptive activities that vary according to their composition, but they had no effect on TNFα titers. None of the essential oils was as effective as CBD. The researchers suggest that terpenoids may be used to diminute acute inflammation effect, whereas the cannabinoids to inhibit chronic inflammation symptoms.
Type of Study: Animal Study
Study Result: Positive
Study Location(s): Israel
Year of Pub: 2018
Cannabinoids Studied: Cannabidiol (CBD)
Phytocannabinoid Source: Isolate
Chemotype: Chemotype III
Terpenes Studied: ß-Caryophyllene, Humulene, Limonene, Myrcene, Ocimene, Pinene, Terpinolene
DOSING DETAILS 
Study Dosing Objective: Effective Dose
Established Protocol: Effective dose
Route of Administration: Injection
Dosing Regimen: CBD 5 mg/kg or terpenoid-rich essential oils 10, 25, or 50 mg/kg
Clinical Relevance: Terpenoid-rich essential oils exert anti-inflammatory and antinociceptive activities in vitro and in vivo, but none of the essential oils were as effective as purified CBD. CBD might be useful in chronic inflammation.
Link to study
