PRIMARY STUDY

The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines

Key Findings:  Only nerolidol showed a degree of synergism in all cell lines where it was possible to test for it. The effect from the combination of DOX with sesquiterpenes was not different from the effect of sesquiterpenes alone in the CEM/ADR cell line, despite the appearance of the largest shift of intracellular DOX concentrations. Further tests suggested the interaction of sesquiterpenes with efflux transporters as the possible mechanism of synergism with DOX.