PRIMARY STUDY

The cannabinoid receptor 2 agonist, β-caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged male mice

Key Findings:  Based on previously discovered properties of β-caryophyllene (BCP) to induce its anti-inflammatory effects, improve memory and an increase lifespan for example these researchers confirmed that deficits in working memory and an age-related increase in pro-inflammatory cytokines were both reversed by BCP.

Type of Study:  Animal Study

Study Result:  Positive

Study Location(s):  United States

Year of Pub:  2019


Cannabinoids Studied: 

Phytocannabinoid Source:  Not Applicable

Terpenes Studied:  ß-Caryophyllene

Receptors Studied:  CB2

Ligands Studied:  Anti-inflammatory cytokines

DOSING DETAILS   

Study Dosing Objective:  Effective Dose

Established Protocol:  Effective dose

Dosing Regimen:  β-caryophyllene 100–300 mg/kg

Clinical Relevance:  β-caryophyllene improved working memory and decreased IL-23 levels in aged mice and appears to reverse age-associated impairments in memory and modulate cytokine production.



Link to study