Key Findings:  These translational findings strongly support a role for differential miRNA/gene induction and T cell activation in Δ9-THC-mediated suppression of intestinal inflammation in HIV/SIV and potentially other chronic inflammatory diseases of the intestine.
Type of Study:  Animal Study
Study Result:  Positive
Study Location(s):  United States
Year of Pub:  2019
Cannabinoids Studied:  Tetrahydrocannabinol (THC)
Phytocannabinoid Source:  Not Applicable
Chemotype:  Chemotype I
Receptors Studied:  CB2, PPAR - Gamma
Ligands Studied:  Pro-inflammatory cytokines
DOSING DETAILS   
Study Dosing Objective:  Effective Dose
Established Protocol:  Effective dose
Route of Administration:  Injection
Cannabinoid Ratio:  (THC)   0    
Dosing Regimen:  THC at 0.18 mg/kg on a daily basis.
Titration:  Dose was increased for each subject to 0.32 mg/kg, over a period of ~2 weeks when responding was no longer affected by 0.18 mg/kg
Treatment Duration:  180 days
Clinical Relevance:  Δ9-THC shows the ability to prevent lymph node fibrosis, a serious irreversible consequence of HIV-induced chronic inflammation.