PRIMARY STUDY

Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

Key Findings:  Cannabinoids could be a precious resource for future treatment of both acute and chronic diseases. Considering specific cultivars containing different cannabinoid constituents, it might be possible to select the appropriate variety enriched of a specific class of compounds to be used for a specific disease. Moreover, if we consider that the treatment of most degenerative diseases is still far from achieving full success, the research on hemp and CBD extracts is strongly encouraged in order to have enough data for a rational clinical application.

Type of Study:  Meta-analysis

Study Result:  Positive

Study Location(s):  Italy

Year of Pub:  2018


Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabinol (THC), Cannabidiolic Acid (CBD-a), Anandamide (AEA), 2-Arachidonoyl Glycerol (2-AG), Pharma THC, Pharma THC:CBD, Pharma CBD

Phytocannabinoid Source:  Not Applicable

Chemotype:  Chemotype I, Chemotype II, Chemotype III

Terpenes Studied:  ß-Caryophyllene, Myrcene

Receptors Studied:  CB1, CB2, GPCR 18, GPCR 55, TRPV1, TRPV2, PPARs

Ligands Studied:  Anti-inflammatory cytokines, Serotonin, Pro-inflammatory cytokines, Neurotransmitter (unspecified/other)